Alzheimer's Disease
Alzheimer's disease is a slowly progressive, degenerative disorder of the brain that eventually results in abnormal brain function and death. The disease was first described in 1907 by a German physician, Dr. Alois Alzheimer(1864-1915). In the neurological autopsy on the brain of a 56-year-old woman Auguste D., of Frankfurt, who died after several years of progressive mental deterioration marked by increasing confusion and memory loss. Taking advantage of a then-new staining technique, he noticed an odd disorganization of the nerve cells in her cerebral cortex, the part of the brain responsible for reasoning and memory. The cells were bunched up like a rope tied in knots. He termed the strange nerve bundles neurofibrillary tangles. He also noted an unexpected accumulation of cellular debris around the affected nerves, which he termed senile plaques. In a medical journal article published in 1905, Alzheimer speculated that the nerve tangles and plaques were responsible for the......
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