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Summary
Mycobacterium tuberculosis is a successful pathogen that over-
comes numerous challenges presented by the immune system of the
host. This bacterium usually establishes a chronic infection in the host
where it may silently persist inside a granuloma until, a failure in host
defenses, leads to manifestation of the disease. None of the
conventional anti-tuberculosis drugs are able to target these persisting
bacilli. Development of drugs against such persisting bacilli is a
constant challenge since the physiology of these dormant bacteria is
still not understood at the molecular level. Some evidence suggests
that the in vivo environment encountered by the persisting bacteria is
anoxic and nutritionally starved. Based on these assumptions,
anaerobic and starved cultures are used as models to study the
molecular basis of dormancy. This review outlines the problem of
persistence of M. tuberculosis and the various in vitro models used to
study......

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Approximate Word Count: 7295
Approximate Pages: 30 (250 words per double-spaced page)

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