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One of the obstacles to successful cell-replacement therapy is apoptotic death of donor cells following transplantation [3, 5]. Adult retinal stem cells (RSC) were recently discovered in mammals [1, 7, 25] and could be harnessed to treat retinal degeneration disorders. However, first these cells must be successfully delivered to the diseased eye. A potential solution to the loss of transplanted tissue is over-expression of an anti-apoptotic protein by adult RSC, which would render the cells resistant to post-transplant apoptosis. The desired protein can be delivered to the cells via a viral vector, such as adeno-associated virus (AAV). AAV is a commonly used viral vector because it is not associated with any known disease and, in the absence of its helper virus, it integrates its genome into that of the host. There are different strains of AAV associated with varying infection efficiencies in different target cells [14]. To determine which strain is best suited to deliver......

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