The Role Of Dopamine As An Antidepressant Medication
The neural circuitry that controls mood under normal and abnormal conditions remains incompletely understood. Depression is the most common of the affective disorders and is linked worldwide to disability and premature death (Rang H.P., Dale M.M., Ritter J.M., & Moore P.K, 2003). Over the past four decades, inhibitors of biogenic amine reuptake have been the main drug therapy for the treatment of major depression, specifically 5-hydroxytryptamine (serotonin) reuptake inhibitors (SSRIs), serotonin/norepinephrine reuptake inhibitors (SNRIs) and tricyclic antidepressants. The purpose of this essay is to hypothesis as to why there are not more antidepressant drugs that directly affect dopamine in the brain. A possible reason is the findings that though dopamine is shown to have a role in the mesolimbic pathway, the role of dopamine in neurotransmission and the effect of manipulation of levels through antidepressants are still largely unknown. The limited focus on dopamine could also......
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