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Nanocomposite scaffolds of poly (lactide-co-glycolide) and hydroxyapatite surface-grafted
with poly (L-lactide) for bone replacement and tissue engineering.
Swati S Bogam
South Dakota School of Mines & Technology, BME 792


Abstract
Nanocomposites of hydroxyapatite (HAP) surface-grafted with poly (L-lactide) (PLLA) (g-HAP)
have improved interface compatibility, mechanical property and biocompatibility and hence have
a wide application for bone fixation materials. In this paper, a 3-D porous scaffold of g-
HAP/poly (lactide-co-glycolide) (PLGA) fabricated using the solvent casting/particulate leaching
method to investigate its applications in bone replacement and tissue engineering is discussed.
The composite of un-grafted HAP/PLGA and neat PLGA are used as controls. In vivo
mineralization and osteogenesis investigated by intramuscular implantation and replacement for
repairing radius defects of rabbits will also be discussed. More uniform distribution of......

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Approximate Word Count: 4306
Approximate Pages: 18 (250 words per double-spaced page)

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