Huntington's Disease
Huntington's Disease
Background
Huntington's disease is inherited as an autosomal dominant disease that gives
rise to progressive, elective (localized) neural cell death associated with
choleric movements (uncontrollable movements of the arms, legs, and face) and
dementia. It is one of the more common inherited brain disorders. About 25,000
Americans have it and another 60,000 or so will carry the defective gene and
will develop the disorder as they age. Physical deterioration occurs over a
period of 10 to 20 years, usually beginning in a person's 30's or 40's. The gene
is dominant and thus does not skip generations. Having the gene means a 92
percent chance of getting the disease. The disease is associated with increases
in the length of a CAG triplet repeat present in a gene called 'huntington'
located on chromosome 4. The classic signs of Huntington disease are progressive
chorea, rigidity, and dementia, frequently associated with seizures. Studies &
Research Studies were done......
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