Review Of Arginine-482 Is Not Essential For The Transport Of Antibiotics, Primary Bile Acids And Unconjugated Sterols By The Human Breast Cancer Resistance Protein (abcg2)
The breast cancer resistance protein has been found to be a transporter that extrudes various anticancer drugs from cells, resulting in multi-drug resistance. Recent studies on tissue distribution of BCRP (breast cancer resistance protein) showed that the protein is expressed in the apical membrane of cells in tissues with excretory functions, such as luminal membrane of villous epithelial cells in small and large intestines, the apical pole of the trophoblast cells in the placenta, and apical membranes of capillary vessels in the blood-brain barrier, ducts and lobules of the breast. These findings are consistent with the belief that BCRP plays a role in the disposition and pharmacological activity of a broad range of compounds. Other early studies on BCRP revealed that some drug-selected mammalian cell lines expressing BCRP demonstrate resistance to cationic rhodamine 123 and anthracyclines due to the presence of a neutral G (glycine), T (threonine), S (serine) or M (methionine)......
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