Studying Of Alzheimer¡¦S Disease
Introduction
Alzheimer¡¦s disease (AD) was first reported and named after the patient in 1907, Alois Alzheimer. It is the leading cause of dementia in the world, affecting 12 million people worldwide. Symptoms of the disease include memory loss, temporal and geographic disorientation, resulting failure to maintain balance of self, impairment of judgment, deterioration of problem solving, and deterioration of language abilities. AD is caused by the formation of plaque and neurofibrillary tangles (NFTs) leading to extensive neuron death in the brain and results in a destructive pathway. Some other factor causing AD are over expression of amyloid precursor protein (APP), presenilins, or tau protein genes to cause the over-production and build up of the plague. This paper explores these neuro-pathological problems that leads to the developing of AD in rodent transgenic animal and non-rodent transgenic animal such as the fruit fly Drosophila melanogaster and the nematode......
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