Alzheimer Disease Fact Sheet
1. Pathophysiology:
i) Biological Basis and Pathology:
Alzheimer disease is a progressive, degenerative disease which is the leading cause of dementia worldwide in adults (Gauthier et al. 1997). The disease is a chronic disease primarily affecting neurological functioning in the elderly, though it is occasionally diagnosed in earlier age (Crowley 2004). The ten warning signs, or symptoms, of Alzheimer disease according to the Alzheimer Society of Canada are progressive memory loss, difficulty performing regular tasks, language problems, disorientation of time and place, decreased judgment, problems with abstract thinking, misplacing items, changes in behaviour, personality changes, and loss of initiative (2005). In affected patients, the disease is characterized by altered physiology of the brain, mainly in the temporal and hippocampal regions (Gauthier et al.1997). Although patients not suffering from dementia may also exhibit considerable neuronal loss in the cerebral grey......
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