Inflammation Of The Joints
INFLAMMATION OF THE JOINTS
This auto-immune reaction causes inflammation of the joints, particularly the synovial membrane that lines them. If the process continues, damage to the cartilage and other soft tissue can cause joint deformities.
The effects differ from person to person. Most people first become aware of pain, swelling and stiffness in the small joints of the hands or feet.
So in chronic inflammation, when the antigen is presented on the MHCII of the APC,the Th cell is recognize this and is activated, where it will stimulate other cells in the joint to produce cytokines that are central mediators of the synovial reaction.
It will secrete cytokines(IL-4) to activate the Bcells which will produce the antibodies-IgG and IgM classes which will be deposited in the tissue and will subsequently lead to the activation of serum complement cascade and recruit more phagocytic arm of the immune response which further exacerbate the inflammation of the synovium.
It will also......
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