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Lsd

http://www.askpat.colostate.edu/HotTopicHallucinogenics.htm

Kd = 6 nM
Oelszner W Jr. Displacement of specific serotonin and lysergic acid diethylamide binding by Ergalgin, a new antiserotonin drug. Acta Biol Med Ger. 1980;39(8-9):897-901.

LSD is not produced naturally by humans. It is synthesized in a laboratory and then ingested or absorbed through the skin. Very small doses are needed to induce a hallucinogenic effect (20-100 micrograms), yet only 1% reaches the brain.1 The half-life of the drug ranges from 3-5 hours.2 LSD is inactivated in the liver and then excreted.
In 1978, LSD researchers seemed to be uncertain about the make-up of the serotonin (5-HT) receptor family. They only had data to indicate the presence of one receptor, and at least 13 variants of the receptor have now been identified.3 Furthermore, serotonin was thought to exert its effect through dopaminergic and adrenergic systems as well. LSD appears to be a specific antagonist to 5-HT-2 receptor......


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Approximate Word Count: 1130
Approximate Pages: 5 (250 words per double-spaced page)

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